Local UV‐induced DNA damage in cell nuclei results in local transcription inhibition
نویسندگان
چکیده
منابع مشابه
Transcription of superhelical DNA from cell nuclei.
Structures resembling nuclei may be released by gently lysing human or frog cells in solutions containing non-ionic detergents i nd 1.95 M NaC1. These structures, or nucleoids, sediment in sucrose gradients containing intercalating agents in the manner characteristic of DNA that is intact, supercoiled and circular. They are depleted of nuclear protein and contain no endogenous RNA polymerase ac...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2001
ISSN: 1469-221X,1469-3178
DOI: 10.1093/embo-reports/kve224